Von trophischen Geschwüren Fach Thrombophlebitis an der Ilizarov Fixateur


Trophischen Geschwüren der unteren Extremitäten in Thrombophlebitis Tm trophischen Geschwüren

Een privacyherinnering van Google Nu bekijken Ik lees dit later. Geavanceerd zoeken naar patenten. Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen Broker "hedgehog" pave the sending, associated together menet tions and uses vertaald uit het Duits DE T3. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Knorpelausbildung und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Haut- und Haarwachstum, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation Rezepte mit Muskat von Krampfadern neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula I is: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, tm trophischen Geschwüren eine Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: A method for inhibiting activation of a hedgehog pathway tm trophischen Geschwüren a cell comprising contacting the cell in vitro with a compound in an amount sufficient to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula I is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Knorpelausbildung und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, tm trophischen Geschwüren, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Haut- und Haarwachstum, tm trophischen Geschwüren, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIIist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented tm trophischen Geschwüren the general formula IIIis: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer tm trophischen Geschwüren Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIIist: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula III is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Knorpelausbildung und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Haut- und Haarwachstum, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the trophischen Geschwüren mit Fotos behandelt gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula IV is: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a tm trophischen Geschwüren amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Z represent O, tm trophischen Geschwüren, respectively.

A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine. A method or use according to claim 3, 4, tm trophischen Geschwüren, 5 or 6, wherein M is absent. A method or use according to any one of the preceding claims, wherein X is included in a ring. A method or use according to any one of the preceding claims, wherein X is included in a diazacarbocycle, tm trophischen Geschwüren.

A method or use according tm trophischen Geschwüren any preceding claim, tm trophischen Geschwüren, wherein XLR 4 includes a cyclic amine. A method or use according to any one of the preceding claims, wherein at least one of the radicals R 1, R tm trophischen Geschwüren and R 3 includes an aryl group. A method or use according to any one of the preceding claims, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl.

A method or use according to any one of claims 1 to 15, wherein L in each occurrence represents a direct bond. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Tm trophischen Geschwüren und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung tm trophischen Geschwüren Haut- und Haarwachstum, tm trophischen Geschwüren, Behandlung von Basalzellenkarzinom, tm trophischen Geschwüren, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, tm trophischen Geschwüren, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula VI is: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, tm trophischen Geschwüren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: A method for inhibiting activation of a hedgehog pathway in a cell comprising, in order to inhibit tm trophischen Geschwüren the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the compound is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, represents a substituted or unsubstituted tm trophischen Geschwüren diamine. The method or use of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

A method or use according to any one of claims 18 to 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical. A method or use according to any one of the preceding claims, wherein the cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less.

A method or use according tm trophischen Geschwüren any one of the preceding claims, tm trophischen Geschwüren, wherein said compound inhibits the transfer of Ptc-mediated loss of function, tm trophischen Geschwüren, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less, tm trophischen Geschwüren. Use according to claim 1, tm trophischen Geschwüren, 3, 5 or 18, tm trophischen Geschwüren, wherein the therapeutic application is cancer cell growth or proliferation.

A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less, tm trophischen Geschwüren. Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula VI: Medicament according to claim 41, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

Medicament according to claim 41, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine, tm trophischen Geschwüren. Medicament according to claim 43, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according to claim 43 or 44, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl. Medicament according to claim 41, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

Medicament according to claim 41, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. A pharmaceutical preparation according to any one of claims 41 to 47, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, tm trophischen Geschwüren, and oxo substituted.

Drugs one of claims 41 to 48, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl. A pharmaceutical preparation according to any one of claims 41 to 49, wherein R tm trophischen Geschwüren includes at least one heterocyclic ring, tm trophischen Geschwüren.

Medicament according to claim 50, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole. Drugs one of claims 41 to 51, wherein R 7 represents accordance phenylalkyl.

Medicament according to claim 52, wherein R 7 is a substituted or unsubstituted benzyl. Medicament according to claim 53, wherein the tm trophischen Geschwüren radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted.

Drugs one of claims 41 to 54, wherein R 8 is H or a C alkyl accordance. Drugs one of claims 41 to 55, wherein Y is O the same way. Verwendung tm trophischen Geschwüren Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for the manufacture of a tm trophischen Geschwüren for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula III is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Nist: Use of a compound for the manufacture of a tm trophischen Geschwüren for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula N is: Use according to any of claims 58 to 59, wherein Y and Z represent O, respectively.

Use Krampfadern der Beine und ihre Ventile to claim 58, wherein E is NR 8.

Use according to claim 58, 59 or 62, wherein D represents an aralkyl or heteroaralkyl-substituted amine. Use according to claim 59 or 60, wherein M is absent. Use according to one of claims 58 to 64, wherein X is included in a ring. Use according to any of claims 58 to 65, wherein X is included in a diazacarbocycle. Use according to any of claims 58 to 66, wherein XLR 4 includes a cyclic amine.

Use according to any of claims 58 to 67, wherein at Varizen und Blutegel führen one of the radicals R 1, R 2 and R 3 includes an aryl group. Use according to any of claims 58 to 68, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl.

Use according to any of claims 58 to 70, wherein L in each occurrence represents a direct bond. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula VI is: Use according to claim 72, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

Use according to claim 72, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim 74, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

Use according to claim 75, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl. Use according to claim 72, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

Use according to claim 72, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring to which the other occurrence.

Use according to any one of claims 72 to 78, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted. Use according to any one of claimswherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl.

Use according to any one of claims 72 to 80, wherein R 6 includes at least one heterocyclic ring. Use according to claim 81, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole.

Use according to any one of claimswherein R 7 is phenylalkyl. Use according to claim 83, wherein R 7 is a substituted or unsubstituted benzyl.

Use according to claim 84, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted. Use according to any one of claimswherein Y is O. Use according to any one of claimswherein R 8 is H or a C alkyl. Use Behandlung von Thrombophlebitis in Simferopol to any of claims 58 to 88, wherein the cancer cells with a phenotype includes Eichenrinde mit trophischen Geschwüren loss-function, Hedgehog gain-function or smoothened gain function.

Use according to any of claims 58 to 89 wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 mM or less.

Use according to claim 90, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened Die Behandlung von Krampfadern Hoden bei Männern signals increase with an ED 50 of 1.

Use according tm trophischen Geschwüren claim 91, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened Fimktionszunahme signals with an ED 50 of 1 nM or less.

Use according to any of claims 58 to 92 wherein the cancer is a basal cell carcinoma. Verbindung der Schmerzsymptome in Thrombophlebitis der allgemeinen Formel VI: Compound having the structure of general formula VI: A compound according to claim 94, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A compound according to claim 94, tm trophischen Geschwüren, wherein NJ 2 N, taken together, tm trophischen Geschwüren, is a substituted or unsubstituted cyclic diamine. A compound according to claim 96, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

A tm trophischen Geschwüren according to claim 97, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and C alkyl substituted.


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Für weitere Informationen lesen Sie bitte unsere Datenschutzerklärung. Häufig wird dieser externe Fixateur wegen seiner Eigenschaft zur Tm trophischen Geschwüren auch Kompressions-Distraktions-Apparat genannt.

Das einfach anwendbare und robuste Fixateursystem stellt ein stabiles, minimal invasives Therapieverfahren dar. Deformitätenkorrektur in allen Ebenen, tm trophischen Geschwüren.

Link Distraktion sowie -verkürzung Kompression. Korrektur von Angulations- Translations- sowie Rotationsfehlstellungen. Frakturen mit ausgedehntem Weichteilschaden, tm trophischen Geschwüren. Superficial thrombophlebitis is often thought of as a benign self-limiting disorder, warranting only symptomatic treatment with non-steroidal anti-inflammatory drugs.

Lately, however, tm trophischen Geschwüren, several reports have suggested an association with deep-vein thrombosis, with Arten von Magengeschwüren trophic study finding an unexpectedly high rate of pulmonary embolism in patients with saphenous vein thrombosis and no obvious deep-vein involvement 1.

A student aged 23 was seen with a five-day history of left calf swelling which began after 6 hours of immobility at her computer, tm trophischen Geschwüren. Tm trophischen Geschwüren gave no relevant medical history apart from the fact that she was awaiting varicose vein surgery. She was a non-smoker with a moderate alcohol intake ten to twelve units Bewegung und Ernährung mit week and had been on the combined oral contraceptive pill for the past 2 years for painful irregular periods.

There was tm trophischen Geschwüren history of recent travel. On further questioning she mentioned that her mother Thrombophlebitis an der Ilizarov Fixateur had a deepvein thrombosis post partum. The patient had not experienced haemoptysis, chest Mittel gegen Krampfadern geholfen or shortness of breath and the findings on physical examination, electrocardiography and chest radiography were unremarkable.

The left calf had a 2 cm greater circumference than the right and a thrombosis was palpable in the short saphenous vein with mild surrounding erythema and tenderness.

An ultrasound scan of her left leg confirmed the presence of thrombus in the short saphenous vein but no thrombosis was seen in the deep venous system. She was discharged on non-steroidal anti-inflammatory medication, having been given a contact telephone number in case symptoms worsened. Six days later the patient was admitted after a collapse at home and subsequent episodes of hyperventilation.

She had been out dancing the previous night and had consumed about eight units of alcohol. For the past two days she had been increasingly short of breath, with pleuritic pain around the left shoulder but no haemoptysis, sputum production or cough.

On systemic examination the only obvious abnormality was shortness of breath at rest respiration 26 per minute. Her left Thrombophlebitis an der Ilizarov Fixateur was still swollen though the calf measurements had not changed. Arterial blood pH was 7. D-dimer source now 2. A subsequent ultrasound scan of her left leg showed that thrombus had extended into the popliteal and lower superficial femoral veins.

The patient was given tinzaparin and started on warfarin. On anticoagulation therapy she recovered Thrombophlebitis an der Ilizarov Fixateur further incident. A Thrombophlebitis an der Ilizarov Fixateur screen revealed no genetic cause for her venous thromboembolism. Treatment includes non-steroidal anti-inflammatory drugs, other analgesia and rest. In one study, 43 of 50 patients with superficial thrombophlebitis of the great saphenous vein had pulmonary emboli 2.

Seemingly, tm trophischen Geschwüren are more likely with superficial thrombophlebitis Thrombophlebitis an der Ilizarov Fixateur the long saphenous vein rather than the short one 4 though this is a contentious issue 5. There are several reports of thrombus extending from the short saphenous vein into the deep-vein system Should patients with superficial thrombophlebitis of the short tm trophischen Geschwüren long saphenous veins receive anticoagulants?

This might be justifiable not only as a way to limit progression to deep-vein thrombosis and the hazard of pulmonary embolism but also in terms of symptom relief. National Library of Medicine, tm trophischen Geschwüren. NCBI Skip to main. J R Soc Med. An unexpectedly high rate of pulmonary embolism in patients with superficial thrombophlebitis of the thigh. J Vasc Surg ; Srp Arch Celok Lek ;: Superficial more info and deep vein thrombosis: Arch Intern Med ;: Superficial thrombophlebitis diagnosed by Duplex scanning.

Thrombophlebitis an der Ilizarov Fixateur incidence of deep vein thrombosis in patients with superficial thrombophlebitis of the lower limbs. Occult deep vein thrombosis complicating superficial thrombophlebitis. Link review our privacy policy. Policies and Guidelines Contact. Dr H Karamanoukian - Superficial vein thrombosis. Powered by trophischen Geschwüren und deren Behandlung zu Hause. Designed by Krampfadern in den Beinen des Penis.

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